New Subcontract Proposals Open!

Proposals are now being accepted for the National COVID Cohort Collaborative (N3C) PHASTR - N3C Public Health Answers to Speed Tractable Results.  See the N3C website for submission details and timelines N3C PHASTR | N3C (

The N3C PHASTR initiative is a new opportunity to use N3C data to provide fast actionable analyses on high-impact COVID-19 public health questions.  It’s also an opportunity to increase community engagement on using big data for research and machine learning best practices. 

Individuals or teams can apply for N3C PHASTR subcontracts to address specific public health questions.  There will be multiple public health questions subcontractor opportunities throughout the rest of the year.  The initial N3C PHASTR questions currently open for proposals are:

  1. Does the use of UDCA (ursodeoxycholic acid)  at baseline reduce the incidence and/or severity of COVID-19?  
  2. Use of the N3C enclave and machine learning to create generalizable algorithms that predict patient outcomes at (a) diagnosis, and (b) time of hospitalization.
  3. Is Long COVID associated with an increased risk of mortality?

These applications close February 15, 2023.

Submission Process:
Offerors (individuals/teams) applying for a subcontract as part of the N3C PHASTR will submit a proposal using the N3C Data Enclave by following the instructions listed on the N3C PHASTR webpage. All work will be performed utilizing the N3C enclave.

Offerors – those wishing to submit a proposal in response to a N3C PHASTR public health-related research question - will access the proposal Submission process from the N3C home page where they find a new button labeled "Public Health Proposal".

The N3C PHASTR submission package consists of the following components that offerors must include in their proposals: Project Summary, Strategy for Cohort Identification, Analytics Approach, and Justification. 

Who Can and Cannot Apply:
Any individual or team with appropriate expertise, experience, and resources can submit a proposal, provided there is no real or apparent conflict of interest.

All offerors must follow all registration and data access processes associated with the environment, including meeting the access requirements as described here.